Preparation of biodegradable Electrospun-nanofibers based on wheat gluten containing doxorubicin as a drug delivery system

Document Type : Research Paper

Authors
Elham Arkan 1
faranak aghaz 2
1 2. Nano Drug Delivery Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran.
2 Nano Drug Delivery Research Center Kermanshah University of Medical Sciences (KUMS) Kermanshah, Iran
10.22034/cmr.2024.2262
Abstract
Dermatological treatment of many anticancer drugs using wheat gluten nanofibers as a delivery system for doxorubicin is prepared by electrospinning. Doxorubicin drug delivery through the skin is suggested to reduce side effects. Nanofibers were characterized by scanning electron microscopy, Fourier transform infrared testing, X-ray diffractometry, thermal gravimetry, and differential thermal analysis. SEM images showed that the addition of polyvinyl alcohol decreased the fiber diameter. Diameters of 180.14 ± 14.11 nm were obtained for wheat gluten nanofibers containing doxorubicin. In addition, the cytotoxic effect of extracts on 2780A, 12PC, 3PC, and MCF-7 cells is evaluated, which confirmed our results on the MCF-7 cell line. Diameters of 180.14 ± 14.11 nm were obtained for wheat gluten nanofibers containing doxorubicin. In addition, the cytotoxic effect of extracts on 2780A, 12PC, 3PC, and MCF-7 cells is evaluated, which confirmed our results on the MCF-7 cell line. In addition, the cytotoxic effect of extracts on 2780A, 12PC, 3PC, and MCF-7 cells is evaluated, which confirmed our results on the MCF-7 cell line.

Keywords

Subjects

Cellular and Molecular Research (Iranian Journal of Biology)
Volume 37, Issue 1
Winter 2024
Pages 92-109

  • Receive Date 20 December 2022
  • Revise Date 30 January 2023
  • Accept Date 22 February 2023