Study of association between rs2976394 single nucleotide polymorphism of PSCA gene related to hsa-miR-3934 and suffering from gastric cancer

Document Type : Research Paper


1 Department of Biology,Faculty of Science,Nourdanesh Institute of Higher Education,Meymeh,esfahan,Iran

2 Devision of Cellular and Molecular Biology,Department of Biology,faculty of Science,Isfahan.iran

3 National Institute og Genetic Engeneering and biotechnology,Shahrak-e-Pajoohesh,km 15,Tehran-Karaj Highway,Tehran,Iran


In recent years, gastric cancer ranks as the fifth cause of death and it demands for recognizing biomarkers. To get more information, we used NCBI, miRNA SNP, miRBase, phenomiR, miRWALK2.0 and DAVID data bases as the bioinformatic tools. As was shown in NCBI, one of the genes that showed a close relationship with gastric cancer was PSCA on a locus of 8q2.42. To find recognizing related miRNAs, we used miRNASNP and miRdSNP. There was one SNP of rs2976394, for substitutuion of allele C with T which affected binding affinity of the related microRNA which was hsa-miR-3924. has-miR-3934 has known as one of the most important microRNAs, according to its role in gastric cancer by the data obtained from bioinformatics web sites including phenomiR, and miRWALK2.0. Therefore this miRNA was selected for futrther analyses.Results have shown meaningful association between rs2976394 and incidence of gastric cancer. Also, statistical results have shown significant relation between rs2976394 and H.pylori and metastasis. In addition, there is a conformity between RLN,primary tumor,stage and rs2976394. Finally according to statistical information, Hereditary pattern of Log-additive has chosen.


Main Subjects

Volume 34, Issue 2
June 2021
Pages 206-218
  • Receive Date: 12 September 2018
  • Revise Date: 06 January 2019
  • Accept Date: 12 January 2019
  • First Publish Date: 22 June 2021