TY - JOUR ID - 1227 TI - Investigation of relationship between the C825T polymorphism in GNB3 gene and obesity in the population of Ardabil, Iran JO - Cellular and Molecular Research (Iranian Journal of Biology) JA - CMR LA - en SN - 2383-2738 AU - Nategh, Fatemeh AU - yaghoubi, hashem AU - RajabaliZadeh, Keyvan AD - Department of biology, Ardabil Branch, Islamic Azad University, Ardabil, Iran. AD - Y1 - 2018 PY - 2018 VL - 30 IS - 4 SP - 422 EP - 429 KW - obesity KW - polymorphism C825T KW - gene GNB3 KW - PCR-RFLP DO - N2 - Obesity is currently a risk factor for many diseases and health problems that one of the main causes of its incidenceare genetic factors. One of the genetic factors that recently considered for obesity is polymorphisms of GNB3. This study aimed to investigate the association between C825T polymorphism in GNB3 with obesity in the population of Ardabil. In this case-control study, 100 obese subjects (case group) and 100 healthy subjects (control group) were included basis of their body mass index. 42% of healthy and 44% of obese subjects were male, and 58% of healthy and 56% of obese subjects were female (P = 0.775). The mean age of healthy and obese subjects was 41.5±16.7 and 41.6±13.8, respectively (P<0.001). The TT genotype frequency in obese individuals was significantly greater than its frequency in healthy individuals (38% versus 13%, P=0.0001). Also, the T allele frequency in obese individuals was significantly greater than its frequency in healthy individuals (60% versus 39%, P=0.0029). The Findings showed that TT genotype increases the risk of obesity with an odds ratio of 2.92. In other words, the risk of obesity in people with TT genotype of C825T polymorphism is 75%. The results of this study showed that C825T polymorphism of GNB3 gene is associated with obesity in Ardebil population and can represent one of the possible genetic causes of obesity incidence in this area. UR - https://cell.ijbio.ir/article_1227.html L1 - https://cell.ijbio.ir/article_1227_2ac917767c2ac741fed57cd6b639a1b9.pdf ER -